Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

[HTML][HTML] Feeding the brain: effect of nutrients on cognition, synaptic function, and AMPA receptors

R Fadó, A Molins, R Rojas, N Casals - Nutrients, 2022 - mdpi.com
In recent decades, traditional eating habits have been replaced by a more globalized diet,
rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary …

[HTML][HTML] Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of polycystin-2

Q Wang, RA Corey, G Hedger, P Aryal, M Grieben… - Structure, 2020 - cell.com
Summary Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary
membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in …

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

M Casas, R Fadó, JL Domínguez, A Roig… - Journal of Cell …, 2020 - rupress.org
Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the
ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the …

[HTML][HTML] NRG1, PIP4K2A, and HTR2C as Potential Candidate Biomarker Genes for Several Clinical Subphenotypes of Depression and Bipolar Disorder

A Levchenko, NM Vyalova, T Nurgaliev… - Frontiers in …, 2020 - frontiersin.org
GSK3B, BDNF, NGF, NRG1, HTR2C, and PIP4K2A play important roles in molecular
mechanisms of psychiatric disorders. GSK3B occupies a central position in these molecular …

Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia

OY Fedorenko, AJM Loonen, F Lang… - International Journal …, 2015 - academic.oup.com
Background: Tardive dyskinesia is a disorder characterized by involuntary muscle
movements that occur as a complication of long-term treatment with antipsychotic drugs. It …

[HTML][HTML] Novel Kv7. 1-phosphatidylinositol 4, 5-bisphosphate interaction sites uncovered by charge neutralization scanning

K Eckey, E Wrobel, N Strutz-Seebohm, L Pott… - Journal of biological …, 2014 - ASBMB
K v 7.1 to K v 7.5 α-subunits belong to the family of voltage-gated potassium channels (K v).
Assembled with the β-subunit KCNE1, K v 7.1 conducts the slowly activating potassium …

Membrane‐tethered AKT kinase regulates basal synaptic transmission and early phase LTP expression by modulation of post‐synaptic AMPA receptor level

Y Pen, N Borovok, M Reichenstein, A Sheinin… - …, 2016 - Wiley Online Library
The serine/threonine kinase AKT/PKB plays a fundamental role in a wide variety of neuronal
functions, including neuronal cell development, axonal growth, and synaptic plasticity …

Фармакогенетика тардивной дискинезии

СА Иванова, ОЮ Федоренко, НА Бохан, А Лунен - 2015 - elibrary.ru
В предлагаемой вниманию читательской аудитории монографии освещены
современные гипотезы участия фармакогенетических факторов в патогенезе …

[HTML][HTML] Association of PIP4K2A Polymorphisms with Alcohol Use Disorder

OY Fedorenko, EV Mikhalitskaya, VA Toshchakova… - Genes, 2021 - mdpi.com
Background: Alcohol use disorder (AUD) not only influences individuals and families but
also has a lasting social impact on communities at the national level. Dopaminergic …