Esophageal carcinoma
AK Rustgi, HB El-Serag - New England Journal of Medicine, 2014 - Mass Medical Soc
The 5-year survival rate in esophageal cancer, although poor, has improved over the past
decade. This review discusses the epidemiologic aspects, pathogenesis, prevention, and …
decade. This review discusses the epidemiologic aspects, pathogenesis, prevention, and …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …
key observation is the disruption of cellular homeostasis, often coinciding with disease …
Global trends in esophageal cancer
BACKGROUND AND OBJECTIVES Esophageal Cancer (EC) is a lethal malignancy with
poor prognosis and significant variations in the incidence, mortality, and histopathology …
poor prognosis and significant variations in the incidence, mortality, and histopathology …
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
Y Zhang, Y Zhang, K Sun, Z Meng… - Journal of molecular cell …, 2019 - academic.oup.com
The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …
[HTML][HTML] Zinc transporters as potential therapeutic targets: An updated review
Zinc is an essential trace element that plays important roles in the regulation of various
physiological responses in the body. Zinc deficiency is known to cause various health …
physiological responses in the body. Zinc deficiency is known to cause various health …
Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters
Zinc is an essential micronutrient that supports all living organisms through regulating
numerous biological processes. However, the mechanism of uptake regulation by …
numerous biological processes. However, the mechanism of uptake regulation by …
Genomic characterization of esophageal squamous cell carcinoma reveals critical genes underlying tumorigenesis and poor prognosis
HD Qin, XY Liao, YB Chen, SY Huang, WQ Xue… - The American Journal of …, 2016 - cell.com
The genetic mechanisms underlying the poor prognosis of esophageal squamous cell
carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in …
carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in …
Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
C Medina-Gomez, JF Felix, K Estrada… - European journal of …, 2015 - Springer
Genome-wide association studies (GWAS) have been successful in identifying loci
associated with a wide range of complex human traits and diseases. Up to now, the majority …
associated with a wide range of complex human traits and diseases. Up to now, the majority …
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer
J Hu - The FEBS journal, 2021 - Wiley Online Library
The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …