[HTML][HTML] Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

SA Rosenberg, NP Restifo, JC Yang… - Nature Reviews …, 2008 - nature.com
Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged
as the most effective treatment for patients with metastatic melanoma and can mediate …

[HTML][HTML] Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation

S Prockop, E Doubrovina, S Suser… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes
(EBV-CTLs) can eradicate EBV-associated lymphomas (EBV-PTLD) after transplantation of …

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

SA Rosenberg, JC Yang, RM Sherry, US Kammula… - Clinical cancer …, 2011 - AACR
Purpose: Most treatments for patients with metastatic melanoma have a low rate of complete
regression and thus overall survival in these patients is poor. We investigated the ability of …

Progress and problems in understanding and managing primary Epstein-Barr virus infections

OA Odumade, KA Hogquist… - Clinical microbiology …, 2011 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human
population. Primary infection is often asymptomatic but results in lifelong infection, which is …

Epstein–Barr virus: 40 years on

LS Young, AB Rickinson - Nature Reviews Cancer, 2004 - nature.com
Epstein–Barr virus (EBV) was discovered 40 years ago from examining electron
micrographs of cells cultured from Burkitt's lymphoma, a childhood tumour that is common in …

Epstein–Barr virus infection

JI Cohen - New England journal of medicine, 2000 - Mass Medical Soc
The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells
cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr. 1 Four years later, in …

BK polyomavirus: clinical aspects, immune regulation, and emerging therapies

GR Ambalathingal, RS Francis, MJ Smyth… - Clinical microbiology …, 2017 - Am Soc Microbiol
SUMMARY BK polyomavirus (BKV) causes frequent infections during childhood and
establishes persistent infections within renal tubular cells and the uroepithelium, with …

[HTML][HTML] Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice

V Dasari, LK McNeil, K Beckett, M Solomon… - Nature …, 2023 - nature.com
The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …

Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial

T Haque, GM Wilkie, MM Jones… - Blood, The Journal …, 2007 - ashpublications.org
We present the results of a multicenter clinical trial using Epstein-Barr virus (EBV)–specific
cytotoxic T lymphocytes (CTLs) generated from EBV-seropositive blood donors to treat …