In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …

During the elongating spermatid stage of spermiogenesis, human sperm chromatin
undergoes a complex transition in which histones are extensively replaced by protamines in …

Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

During male germ cell postmeiotic maturation, dramatic chromatin reorganization occurs,
which is driven by completely unknown mechanisms. For the first time, we describe a …

A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an
important role in the chromatin reorganization required for meiosis and/or spermatogenesis …

DNA in eukaryotic cells is compacted into chromatin, a regular repeated structure in which
the nucleosome represents the basic unit. The nucleosome not only serves to compact the …

Changes in the overall structure of chromatin are essential for the proper regulation of
cellular processes, including gene activation and silencing, DNA repair, chromosome …

Previous studies have shown two homologous chromodomain modules in the HP1 and
Polycomb proteins exhibit discriminatory binding to related methyllysine residues …

Five non-allelic histone H3 variants, H3. 1, H3. 2, H3. 3, H3t and CENP-A, have been
identified in mammals. H3t is robustly expressed in the testis, and thus was assigned as the …