The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Background—Although metabolic reprogramming is critical in the pathogenesis of heart
failure, studies to date have focused principally on fatty acid and glucose metabolism …

The gut microbiota is a key environmental determinant of mammalian metabolism.
Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

Epigenetic information can be inherited through the mammalian germline and represents a
plausible transgenerational carrier of environmental information. To test whether …

We performed silencing and overexpression studies of flavin containing monooxygenase
(FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide …

Maintenance of skeletal muscle mass relies on the dynamic balance between anabolic and
catabolic processes and is important for motility, systemic energy homeostasis, and viability …

Diabetes mellitus is associated with various disorders of the locomotor system including the
decline in mass and function of skeletal muscle. The mechanism underlying this association …

Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac
insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA …