Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management

S Pati, W Irfan, A Jameel, S Ahmed, RK Shahid - Cancers, 2023 - mdpi.com
Simple Summary Obesity has been linked to several common cancers including breast,
colorectal, esophageal, kidney, gallbladder, uterine, pancreatic, and liver cancer. Obesity …

[PDF][PDF] Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment

S Bahadoram, M Davoodi, S Hassanzadeh… - G Ital Nefrol, 2022 - researchgate.net
Renal cell carcinoma (RCC) is the most common type of urogenital cancer. It has a mortality
rate of 30-40% and is more commonly seen in men than women. In addition to gender, other …

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

The trans-ancestral genomic architecture of glycemic traits

J Chen, CN Spracklen, G Marenne, A Varshney… - Nature …, 2021 - nature.com
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic
health. To date, most genetic studies of glycemic traits have focused on individuals of …

Type 2 diabetes and cancer: an umbrella review of observational and mendelian randomization studies

J Pearson-Stuttard, N Papadimitriou… - … Biomarkers & Prevention, 2021 - AACR
Background: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of
developing several common cancers, but it is unclear whether this association is causal. We …

Diabetes, obesity, and cancer—pathophysiology and clinical implications

IC Lega, LL Lipscombe - Endocrine reviews, 2020 - academic.oup.com
Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer

S Christakoudi, E Evangelou, E Riboli, KK Tsilidis - Scientific reports, 2021 - nature.com
Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …

Estimating the magnitude of cancer overdiagnosis in Australia

PP Glasziou, MA Jones, T Pathirana… - Medical Journal of …, 2020 - Wiley Online Library
Objectives To estimate the proportion of cancer diagnoses in Australia that might reasonably
be attributed to overdiagnosis by comparing current and past lifetime risks of cancer. Design …

Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies

SC Larsson, S Burgess - BMC medicine, 2021 - Springer
Background Obesity is a worldwide epidemic that has been associated with a plurality of
diseases in observational studies. The aim of this study was to summarize the evidence from …