Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research

TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Renin-angiotensin system in pathogenesis of atherosclerosis and treatment of CVD

AV Poznyak, D Bharadwaj, G Prasad… - International Journal of …, 2021 - mdpi.com
Atherosclerosis has complex pathogenesis, which involves at least three serious aspects:
inflammation, lipid metabolism alterations, and endothelial injury. There are no effective …

Angiotensin-(1–7): beyond the cardio-renal actions

DG Passos-Silva, T Verano-Braga… - Clinical …, 2013 - portlandpress.com
It is well known that the RAS (renin–angiotensin system) plays a key role in the modulation
of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) …

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

DS Skiba, R Nosalski, TP Mikolajczyk… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Inflammation plays a key role in atherosclerosis. The protective
role of angiotensin 1–7 (Ang‐(1–7)) in vascular pathologies suggested the therapeutic use …

Angiotensin-(1–7) analogue AVE0991 modulates astrocyte-mediated neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 pathway and offers …

R Duan, SY Wang, B Wei, Y Deng, XX Fu… - Journal of …, 2021 - Taylor & Francis
Objective Emerging evidence suggests that brain angiotensin-(1–7)(Ang-(1–7)) deficiency
contributes to the pathogenesis of Alzheimer's disease (AD). Meanwhile, our previous …

Perinatally administered losartan augments renal ACE 2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

J Klimas, M Olvedy… - Journal of cellular …, 2015 - Wiley Online Library
Since the identification of the alternative angiotensin converting enzyme (ACE) 2/Ang‐(1‐
7)/Mas receptor axis, renin‐angiotensin system (RAS) is a new complex target for a …

ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke

T Jiang, L Gao, J Lu, YD Zhang - Current neuropharmacology, 2013 - ingentaconnect.com
The renin-angiotensin system (RAS) in brain is a crucial regulator for physiological
homeostasis and diseases of cerebrovascular system, such as ischemic stroke …

Role of renin-angiotensin system components in atherosclerosis: focus on Ang-II, ACE2, and Ang-1–7

GM Silva, MS França-Falcão, NTM Calzerra… - Frontiers in …, 2020 - frontiersin.org
Atherosclerosis is the leading cause of vascular disease worldwide and contributes
significantly to deaths from cardiovascular complications. There is a remarkably close …