Aims We set out to examine the evidence for an association between cognitive impairment
or dementia and the presence of Type 2 diabetes mellitus (DM). We also sought evidence of …

Mitogen‐activated protein kinase (MAPK) signalling occurs in response to almost any
change in the extracellular or intracellular milieu that affects the metabolism of the cell …

Insulin resistance plays a central role in the development of type 2 diabetes, but the precise
defects in insulin action remain to be elucidated. Glycogen synthase kinase 3 (GSK-3) can …

Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling
pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative …

Glycogen synthase (GS) activity is reduced in skeletal muscle of type 2 diabetes, despite
normal protein expression, consistent with altered GS regulation. Glycogen synthase kinase …

Abstract Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has
recently emerged as a key target in drug discovery. It has been implicated in multiple cellular …

Glycogen synthase kinase 3β (GSK3β) is a key component in many biological processes
including insulin and Wnt signaling. Since the activation of each signaling pathway results in …

Glycogen synthase kinase 3 comprises two isoforms (GSK-3α and GSK-3β) that are
implicated in type II diabetes, neurodegeneration, and cancer. GSK-3 activity is elevated in …

Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar
disorder. Although the underlying mechanism (s) of this mood stabilizer remains …

Notch receptors modulate transcriptional targets following the proteolytic release of the
Notch intracellular domain (NotchIC). Phosphorylated forms of NotchIC have been identified …