Small‐angle scattering for structural biology—Expanding the frontier while avoiding the pitfalls
DA Jacques, J Trewhella - Protein science, 2010 - Wiley Online Library
The last decade has seen a dramatic increase in the use of small‐angle scattering for the
study of biological macromolecules in solution. The drive for more complete structural …
study of biological macromolecules in solution. The drive for more complete structural …
The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses
DD Krueger, LP Tuffy, T Papadopoulos… - Current opinion in …, 2012 - Elsevier
Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion
proteins that play a key role in the formation, maturation, activity-dependent validation, and …
proteins that play a key role in the formation, maturation, activity-dependent validation, and …
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Malignancy is associated with altered expression of glycans and glycoproteins that
contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature …
contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature …
Deletions of NRXN1 (neurexin‐1) predispose to a wide spectrum of developmental disorders
Research has implicated mutations in the gene for neurexin‐1 (NRXN1) in a variety of
conditions including autism, schizophrenia, and nicotine dependence. To our knowledge …
conditions including autism, schizophrenia, and nicotine dependence. To our knowledge …
Neuroligin‐3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses
EC Budreck, P Scheiffele - European Journal of Neuroscience, 2007 - Wiley Online Library
Synaptic adhesion molecules are thought to play a critical role in the formation, function and
plasticity of neuronal networks. Neuroligins (NL1–4) are a family of presumptive …
plasticity of neuronal networks. Neuroligins (NL1–4) are a family of presumptive …
The neuroligins and the synaptic pathway in Autism Spectrum Disorder
L Trobiani, M Meringolo, T Diamanti, Y Bourne… - Neuroscience & …, 2020 - Elsevier
The genetics underlying autism spectrum disorder (ASD) is complex and heterogeneous,
and de novo variants are found in genes converging in functional biological processes …
and de novo variants are found in genes converging in functional biological processes …
The cellular and molecular landscape of neuroligins
MA Bemben, SL Shipman, RA Nicoll, KW Roche - Trends in neurosciences, 2015 - cell.com
A fundamental physical interaction exists across the synapse. It is mediated by synaptic
adhesion molecules, and is among the earliest and most indispensable of molecular events …
adhesion molecules, and is among the earliest and most indispensable of molecular events …
[HTML][HTML] Structures of neuroligin-1 and the neuroligin-1/neurexin-1β complex reveal specific protein-protein and protein-Ca2+ interactions
Neurexins and neuroligins provide trans-synaptic connectivity by the Ca 2+-dependent
interaction of their alternatively spliced extracellular domains. Neuroligins specify synapses …
interaction of their alternatively spliced extracellular domains. Neuroligins specify synapses …
Neuroligin-1 signaling controls LTP and NMDA receptors by distinct molecular pathways
X Wu, WK Morishita, AM Riley, WD Hale, TC Südhof… - Neuron, 2019 - cell.com
Neuroligins, postsynaptic cell adhesion molecules that are linked to neuropsychiatric
disorders, are extensively studied, but fundamental questions about their functions remain …
disorders, are extensively studied, but fundamental questions about their functions remain …
Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders
Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …