Acute optic neuritis is the most common optic neuropathy affecting young adults. Exciting
developments have occurred over the past decade in understanding of optic neuritis …

Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Objective To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness
after optic neuritis (ON) correlate with either visual recovery or impairment. Methods ON can …

Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however,
longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis …

Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis
relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used …

The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which
culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem …

The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …

Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and
other neurologic disorders that affect the anterior visual pathway. Optical coherence …

The effect of extra-fiber structural and pathological components confounding diffusion tensor
imaging (DTI) computation was quantitatively investigated using data generated by both …

We do not have currently satisfactory clinical and anatomical correlates to gauge disability in
multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot …