Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
AJ Morgan, FM Platt, E Lloyd-Evans… - Biochemical …, 2011 - portlandpress.com
Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …
storage cellular compartments with a central role in intracellular Ca2+ signalling …
A primer of NAADP-mediated Ca2+ signalling: from sea urchin eggs to mammalian cells
A Galione - Cell calcium, 2015 - Elsevier
Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …
[HTML][HTML] Activity-dependent exocytosis of lysosomes regulates the structural plasticity of dendritic spines
Z Padamsey, L McGuinness, SJ Bardo, M Reinhart… - Neuron, 2017 - cell.com
Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …
Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles
AJ Morgan, LC Davis, SKTY Wagner, AM Lewis… - Journal of Cell …, 2013 - rupress.org
The endoplasmic reticulum (ER) and acidic organelles (endo-lysosomes) act as separate
Ca2+ stores that release Ca2+ in response to the second messengers IP3 and cADPR (ER) …
Ca2+ stores that release Ca2+ in response to the second messengers IP3 and cADPR (ER) …
[HTML][HTML] An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
Calcium signaling via two-pore channels: local or global, that is the question
Recently, we identified, for the first time, two-pore channels (TPCs, TPCN for gene name) as
a novel family of nicotinic acid adenine dinucleotide phosphate (NAADP)-gated …
a novel family of nicotinic acid adenine dinucleotide phosphate (NAADP)-gated …
[HTML][HTML] Intracellular Ca2+ signalling: unexpected new roles for the usual suspect
Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels
Acidic Ca 2+ stores refer to a collection of H+-and Ca 2+-rich organelles involved in Ca 2+
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …
A novel Ca2+-mediated cross-talk between endoplasmic reticulum and acidic organelles: Implications for NAADP-dependent Ca2+ signalling
V Ronco, DM Potenza, F Denti, S Vullo, G Gagliano… - Cell Calcium, 2015 - Elsevier
Nicotinic acid adenine dinucleotide phosphate (NAADP) serves as the ideal trigger of spatio-
temporally complex intracellular Ca 2+ signals. However, the identity of the intracellular Ca …
temporally complex intracellular Ca 2+ signals. However, the identity of the intracellular Ca …
[HTML][HTML] Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide
Recent studies have demonstrated that the majority of endogenous cannabinoid type 1 (CB
1) receptors do not reach the cell surface but are instead associated with endosomal and …
1) receptors do not reach the cell surface but are instead associated with endosomal and …