The protective role of exercise against age-related neurodegeneration
A Sujkowski, L Hong, RJ Wessells, SV Todi - Ageing Research Reviews, 2022 - Elsevier
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …
multiple organ systems. Exercise improves multiple indices of physical performance and …
Skeletal muscle in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, has been
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy
I Palazzolo, C Stack, L Kong, A Musaro, H Adachi… - Neuron, 2009 - cell.com
Expansion of a polyglutamine tract in the androgen receptor (AR) causes spinal and bulbar
muscular atrophy (SBMA). We previously showed that Akt-mediated phosphorylation of AR …
muscular atrophy (SBMA). We previously showed that Akt-mediated phosphorylation of AR …
Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy
X-linked spinal and bulbar muscular atrophy (SBMA) is characterized by adult-onset muscle
weakness and lower motor neuron degeneration. SBMA is caused by CAG-polyglutamine …
weakness and lower motor neuron degeneration. SBMA is caused by CAG-polyglutamine …
Lumbar multifidus muscle degenerates in individuals with chronic degenerative lumbar spine pathology
B Shahidi, JC Hubbard, MC Gibbons… - Journal of …, 2017 - Wiley Online Library
Histological and cell‐level changes in the lumbar musculature in individuals with chronic
lumbar spine degenerative conditions are not well characterized. Although prior literature …
lumbar spine degenerative conditions are not well characterized. Although prior literature …
Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
Histological evidence of muscle degeneration in advanced human rotator cuff disease
MC Gibbons, A Singh, O Anakwenze, T Cheng… - JBJS, 2017 - journals.lww.com
Background: Cellular remodeling in rotator cuff muscles following a massive rotator cuff tear
is poorly understood. The aim of the current study was to provide histological evidence to …
is poorly understood. The aim of the current study was to provide histological evidence to …
Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
V Crippa, VG D'Agostino, R Cristofani, P Rusmini… - Scientific reports, 2016 - nature.com
Neurodegenerative diseases (NDs) are often associated with the presence of misfolded
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and …
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and …
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
E Molotsky, Y Liu, AP Lieberman, DE Merry - Acta Neuropathologica …, 2022 - Springer
Spinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular
neurodegenerative disease for which there is no cure. The disease is characterized by a …
neurodegenerative disease for which there is no cure. The disease is characterized by a …
Serum creatinine is a biomarker of progressive denervation in spinal muscular atrophy
CRR Alves, R Zhang, AJ Johnstone, R Garner… - Neurology, 2020 - AAN Enterprises
Objective Identifying simple biomarkers that can predict or track disease progression in
patients with spinal muscular atrophy (SMA) remains an unmet clinical need. To test the …
patients with spinal muscular atrophy (SMA) remains an unmet clinical need. To test the …