Microfluidics for pharmaceutical nanoparticle fabrication: The truth and the myth

SI Hamdallah, R Zoqlam, P Erfle, M Blyth… - International journal of …, 2020 - Elsevier
Using micro-sized channels to manipulate fluids is the essence of microfluidics which has
wide applications from analytical chemistry to material science and cell biology research …

The bioavailability of drugs—the current state of knowledge

M Stielow, A Witczyńska, N Kubryń, Ł Fijałkowski… - Molecules, 2023 - mdpi.com
Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …

Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Y Wu, LK Vora, D Mishra, MF Adrianto, S Gade… - Biomaterials …, 2022 - Elsevier
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

[HTML][HTML] Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite pharmaceutical system for the treatment of skin and soft …

QK Anjani, AHB Sabri, J Domínguez-Robles… - Biomaterials …, 2022 - Elsevier
Bacteroides fragilis is one of the most common causative group of microorganisms that is
associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of …

In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications

TG Agnihotri, A Alexander, M Agrawal… - Journal of Controlled …, 2023 - Elsevier
Understanding and establishing a link between the physicochemical characteristics of
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …

A review on solubility enhancement methods for poorly water-soluble drugs

A Ainurofiq, DS Putro, DA Ramadhani… - Journal of Reports in …, 2021 - journals.lww.com
One of the most important parameters in pharmacy is drug solubility. Solubility affects the
efficacy of a drug. Drug solubility has an important role in determining the concentration of a …

In vitro dissolution considerations associated with nano drug delivery systems

R Gupta, Y Chen, H Xie - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Nano drug delivery systems (NDDS) offer promising solution for the translation of future
nanomedicines. As bioavailability and therapeutic outcomes can be improved by altering the …

Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives

R Kumar, AK Thakur, N Banerjee, A Kumar… - Drug Delivery and …, 2023 - Springer
The present work reviews the liquid antisolvent crystallization (LASC) to prepare the
nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and …

Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization

P Saha, H Kathuria, MM Pandey - Journal of Drug Delivery Science and …, 2023 - Elsevier
Rotigotine (RTG) is an anti-Parkinson's drug approved by the USFDA to treat motor and non-
motor symptoms of both early and advanced stages of the disease. However, issues like …

Integrated Continuous Crystallization–-Spherical Agglomeration (CCSA) Process for the Intensified Manufacturing of Atorvastatin Calcium

R Parvaresh, S Ferdoush, S Kshirsagar… - Crystal Growth & …, 2024 - ACS Publications
This study applies an innovative two-stage continuous manufacturing process for
atorvastatin calcium (ASC), focusing on the integration of process intensification through …