The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

Selenium has transitioned from an environmental poison and carcinogen to an essential
micronutrient associated with a broad array of health promoting effects. These beneficial …

Rationale: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins
in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha) …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Selenium compounds that contain selenol functions or can be metabolized to selenols are
toxic via superoxide and H 2 O 2 generation, when ingested at dosages beyond …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Selenoprotein K (SELENOK), an endoplasmic reticulum (ER) resident protein, is regulated
by dietary selenium and expressed at a relatively high level in neurons. SELENOK has been …

Selenium (Se) is an essential dietary trace element participating in the regulation of various
physiological functions in humans, farm animals and poultry through its incorporation into a …

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive
oxygen species, endoplasmic reticulum (ER) stress and inflammation, which has been …