Water plays a central role in the assembly and the dynamics of charged systems such as
proteins, enzymes, DNA, and surfactants. Yet it remains a challenge to resolve how water …

The combination of all-atom molecular dynamics simulations with differential scanning
calorimetry (DSC) has been exploited to investigate the influence of temperature and …

Compaction of DNA by oppositely charged nanoparticles is a fundamental phenomenon in
nature and of great interest to developing therapeutics. In addition, the ability to orthogonally …

Glyconanoparticles made by self-assembled glycopolymers currently are practical and
efficient mimics of the glycocalyx on cell surfaces. Considering the complexity of the …

Antisense oligonucleotides (ASOs) are an important emerging therapeutic; however, they
struggle to enter cells without a delivery vehicle, such as a cationic polymer. To understand …

We report the synthesis, quaternization and self-assembly in aqueous media of novel
amphiphilic and pH responsive triblock terpolymers of the type poly [2-(dimethylamino) ethyl …

Harnessing molecular design principles toward functional applications of ion-containing
macromolecules relies on diversifying experimental data sets of well-understood materials …

Polymer-based gene delivery relies on the binding, protection, and final release of nucleic
acid cargo using polycations. Engineering polymeric vectors, by exploring novel topologies …

Micelleplexes are promising gene delivery vehicles that form when DNA complexes with
polycationic micelles. In this study, the influence of DNA length and topology on the structure …

Triblock copolymer of poly (ethylene glycol)-b-poly (2-dimethylaminoethyl methacrylate)-b-
poly (pyrenylmethyl methacrylate)(PEG-b-PDMAEMA-b-PPy) has been developed for use as …