Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …

More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The
alarmin family has been expanding in terms of both number and the concept. It has recently …

Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …

Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …

Interleukin-33 (IL-33)(NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1
family, which has been linked to important diseases, including asthma, rheumatoid arthritis …