[HTML][HTML] Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
P Holzer - Pharmacology & therapeutics, 2011 - Elsevier
Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …
are expressed by specific neurons and cells within the alimentary canal. They subserve …
Modulation of TRPV1 channel function by natural products in the treatment of pain
MA Abbas - Chemico-biological interactions, 2020 - Elsevier
The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
Herbal compounds and toxins modulating TRP channels
Although the benefits are sometimes obvious, traditional or herbal medicine is regarded with
skepticism, because the mechanism through which plant compounds exert their powers are …
skepticism, because the mechanism through which plant compounds exert their powers are …
TRP channels in COVID-19 disease: potential targets for prevention and treatment
SM Jaffal, MA Abbas - Chemico-Biological Interactions, 2021 - Elsevier
Abstract Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe
acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry …
acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry …
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels
E Cuypers, Y Abdel-Mottaleb, I Kopljar, JD Rainier… - Toxicon, 2008 - Elsevier
In this study, we pharmacologically characterized gambierol, a marine polycyclic ether toxin
which is produced by the dinoflagellate Gambierdiscus toxicus. Besides several other …
which is produced by the dinoflagellate Gambierdiscus toxicus. Besides several other …
Convergent strategies for the total synthesis of polycyclic ether marine metabolites
Covering: up to 2007 Marine polycyclic ether natural products continue to fascinate chemists
and biologists due to their exceptionally large and complex molecular architectures and …
and biologists due to their exceptionally large and complex molecular architectures and …
Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-d …
Gambierol is a potent neurotoxin that belongs to the family of marine polycyclic ether natural
products and primarily targets voltage-gated potassium channels (Kv channels) in excitable …
products and primarily targets voltage-gated potassium channels (Kv channels) in excitable …
Receptor-targeting mechanisms of pain-causing toxins: How ow?
CJ Bohlen, D Julius - Toxicon, 2012 - Elsevier
Venoms often target vital processes to cause paralysis or death, but many types of venom
also elicit notoriously intense pain. While these pain-producing effects can result as a …
also elicit notoriously intense pain. While these pain-producing effects can result as a …
Polymodal transient receptor potential vanilloid type 1 nocisensor: structure, modulators, and therapeutic applications
Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion
channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an …
channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an …
Painful toxins acting at TRPV1
BA Cromer, P McIntyre - Toxicon, 2008 - Elsevier
Many plant and animal toxins cause aversive behaviors in animals due to their pungent or
unpleasant taste or because they cause other unpleasant senstations like pain. This article …
unpleasant taste or because they cause other unpleasant senstations like pain. This article …