Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
[HTML][HTML] MYC as a target for cancer treatment
MJ Duffy, S O'Grady, M Tang, J Crown - Cancer treatment reviews, 2021 - Elsevier
The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …
frequently deregulated driver genes in human cancer. Because of its high prevalence of …
[HTML][HTML] The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice
A Yesbolatova, Y Saito, N Kitamoto… - Nature …, 2020 - nature.com
Protein knockdown using the auxin-inducible degron (AID) technology is useful to study
protein function in living cells because it induces rapid depletion, which makes it possible to …
protein function in living cells because it induces rapid depletion, which makes it possible to …
Epigenetic therapies for cancer
SE Bates - New England Journal of Medicine, 2020 - Mass Medical Soc
Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Ewing sarcoma
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
[HTML][HTML] BRD4 and Cancer: going beyond transcriptional regulation
B Donati, E Lorenzini, A Ciarrocchi - Molecular cancer, 2018 - Springer
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
A gene–environment-induced epigenetic program initiates tumorigenesis
Tissue damage increases the risk of cancer through poorly understood mechanisms. In
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
Bromodomains: a new target class for drug development
AG Cochran, AR Conery, RJ Sims III - Nature Reviews Drug Discovery, 2019 - nature.com
Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …
found in proteins with varied functions, were highly tractable small-molecule targets. This is …
[HTML][HTML] Transcriptional addiction in cancer
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …
programs. These dysregulated programs can cause cancer cells to become highly …
Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress
ZG Gong, Y Zhao, ZY Wang, RF Fan, ZP Liu… - Journal of hazardous …, 2022 - Elsevier
Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major
target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal …
target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal …