Dimethylarginine Dimethylaminohydrolase 2 (DDAH 2) Gene Polymorphism, Asymmetric Dimethylarginine (ADMA) Concentrations, and Risk of Coronary Artery …

C Xuan, LQ Xu, QW Tian, H Li, Q Wang, GW He… - Scientific Reports, 2016 - nature.com
Asymmetric dimethylarginine (ADMA) has been shown to be an independent predictor of
cardiovascular diseases. Dimethylarginine dimethylaminohydrolase 2 (DDAH 2) promotes …

Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension

HA Seo, SW Kim, EJ Jeon, JY Jeong, SS Moon… - Diabetes Research and …, 2012 - Elsevier
AIMS: The aim of this study was to investigate whether the polymorphism of DDAH2 is
associated with type 2 diabetes and hypertension in Korean population. METHODS: Total …

Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes

FS Mendes, MR Luizon, ACS Lopes… - Revista Brasileira de …, 2024 - SciELO Brasil
Objective: To examine whether the DDAH2 promoter polymorphisms-1415G/A (rs2272592),-
1151A/C (rs805304) and-449G/C (rs805305), and their haplotypes, are associated with PE …

DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study

Y Fan, Q Gao, JX Guan, L Liu, M Hong… - Neural Regeneration …, 2021 - journals.lww.com
Cerebrovascular endothelial dysfunction is involved in the progression of leukoaraiosis.
Asymmetric dimethylarginine is a competitive inhibitor of nitric oxide, which is highly …

T-786C variation in the promoter sequence of human eNOS gene markedly influences its expression level

AM Elakkad, K Abou-Aisha, SI Hassanein… - Drug Discoveries & …, 2017 - jstage.jst.go.jp
This study investigated the role of the T-786C polymorphism (SNP) in the 5'-flanking
sequence of the endothelial nitric oxide synthase gene (eNOS) on its expression level in …

Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction

N Pérez-Hernández, G Vargas-Alarcón… - Experimental and …, 2014 - Elsevier
The purpose of the present study was to establish the role of DDAH gene polymorphisms in
the risk of developing myocardial infarction (MI) in a clinical cohort of Mexican patients. One …

[PDF][PDF] DDAH2 启动子区-1150C/A 多态性与中国汉族人群冠心病的遗传易感性研究

张顺芝, 孙吉, 刘丽华, 陈磊, 陈小平 - 现代生物医学进展, 2014 - biomed.cnjournals.com
摘要目的: 研究DDAH2 启动子区-1150 C/A rs805304 多态性与中国汉族人群冠心病之间的相关
性. 方法: 应用限制性片段长度多态性聚合酶链反应(PCR-RFLP) 的分析方法, 对381 …

二甲精氨酸二甲胺水解酶2 (-449 G/C) G 等位基因与中国东北地区脑白质疏松发病呈正相关: 一项组间配对病例对照双盲研究

Y Fan, Q Gao, JX Guan, L Liu, M Hong, L Jun… - 中国神经再生研究 …, 2021 - sjzsyj.com.cn
脑血管内皮功能障碍参与了白质病变的进展. 不对称二甲基精氨酸是一氧化氮的竞争性抑制剂,
可在脑白质疏松患者中高表达. 二甲精氨酸二甲胺水解酶是一种水解酶, 可负责消除不对称二甲 …

[HTML][HTML] Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population

E Faramarzi, Y Aftabi, K Ansarin, MH Somi… - … of Endocrinology and …, 2021 - SciELO Brasil
Objective: Globally developing metabolic syndrome (MetS) prevalence as a major health
problem can be related to multiple factors of genetic and environmental …

[PDF][PDF] Nitric oxide regulating proteins as biochemical and genetic markers of coronary artery disease

MZ Gad, SM Abdel-Maksoud… - Biomarkers in …, 2016 - researchgate.net
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Despite huge
efforts and great advances in studying the genetic component of CVD, there is still a great …