Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …

In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …

The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T cell functions, but its
role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and …

Human immunodeficiency virus (HIV)-infected macrophages are long-lived cells that sustain
persistent virus expression, which is both a barrier to viral eradication and contributor to …

Introduction of cART in 1996 has drastically increased the life expectancy of people living
with HIV-1. However, this treatment has not allowed cure as cessation of cART is associated …

Eradicating HIV-1 in infected individuals will not be possible without addressing the
persistence of the virus in its multiple reservoirs. In this context, the molecular …

ABSTRACT HIV-infected macrophages are long-lived cells that represent a barrier to
functional cure. Additionally, low-level viral expression by central nervous system (CNS) …

HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To
find strategies toward an HIV cure, detailed understandings of the molecular mechanisms …

Mammals have evolved many antiviral factors impacting different steps of the viral life cycle.
Associated with chromatin-modifying enzymes, the cellular cofactor CTIP2 contributes to HIV …