Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Innate immunity is the first line of host defense against pathogens. Here, through global
transcriptome and proteome analyses, we uncover that newly described cytoplasmic poly …

How the germ line achieves a clean transition from maternal to zygotic gene expression
control is a fundamental problem in sexually reproducing organisms. Whereas several …

Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed
by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory …

Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem
cell self-renewal with differentiation at a population level remain uncharacterized. We find …

Abstract The Caenorhabditis elegans LIN-41/TRIM71 is a well-studied example of a
versatile regulator of mRNA fate, which plays different biological functions involving distinct …

DNA damage response (DDR) is a coordinated network of diverse cellular processes
including the detection, signaling, and repair of DNA lesions, the adjustment of metabolic …

The regulation of mRNA transcription and translation is uncoupled during oogenesis. The
reason for this uncoupling is two-fold. Chromatin is only accessible to the transcriptional …

The stability and processing of cellular RNA transcripts are efficiently controlled via non-
templated addition of single or multiple nucleotides, which is catalyzed by various …

In many organisms, tissue complexity and cellular diversity create a barrier that can hinder
our understanding of gene expression programs. To address this problem, methods have …