Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels
of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There …

Inexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP)
are hallmarks of type 2 diabetes. Previously, we showed that peripheral delivery of …

Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …

Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key
physiological events in the cardiovascular system. These events are regulated by second …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

This large, retrospective case-control study of electronic health records from 56 million
unique adult patients examined whether or not treatment with a Tumor Necrosis Factor …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

cAMP is a second messenger that controls many key cellular functions. The only way to
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …