Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

The neurochemistry of autism

R Marotta, MC Risoleo, G Messina, L Parisi… - Brain sciences, 2020 - mdpi.com
Autism spectrum disorder (ASD) refers to complex neurobehavioral and
neurodevelopmental conditions characterized by impaired social interaction and …

Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Composition of gut microbiota in children with autism spectrum disorder: a systematic review and meta-analysis

L Iglesias-Vázquez, G Van Ginkel Riba, V Arija… - Nutrients, 2020 - mdpi.com
Background: Autism spectrum disorder (ASD) is a public health problem and has a
prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and …

Genetics of glutamate and its receptors in autism spectrum disorder

S Nisar, AA Bhat, T Masoodi, S Hashem, S Akhtar… - Molecular …, 2022 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

[HTML][HTML] Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications

M Nimgampalle, H Chakravarthy, S Sharma… - Ageing Research …, 2023 - Elsevier
Neurotransmitters serve as chemical messengers playing a crucial role in information
processing throughout the nervous system, and are essential for healthy physiological and …

Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501)

Y Du, L Chen, MC Yan, YL Wang, XL Zhong… - Molecular …, 2023 - nature.com
Evidence suggests that neurometabolite alterations may be involved in the pathophysiology
of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic …

[HTML][HTML] Pre/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder

J Zaheer, H Kim, IO Ko, EK Jo, EJ Choi, HJ Lee… - Environment …, 2022 - Elsevier
In common with the increase in environmental pollution in the past 10 years, there has also
been a recent increase in the prevalence of autism spectrum disorder (ASD). In this regard …