Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …

Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

We recently reported the scalable in vitro production of functional stem cell-derived β-cells
(SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 …

Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …

Differentiation of insulin-producing pancreatic β cells from induced pluripotent stem cells
(iPSCs) derived from patients with diabetes promises to provide autologous cells for …

Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly
generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …