Membranes surrounding cells or organelles represent barriers to proteins and other
molecules. However, specific proteins can cross membranes by different translocation …

Single domain antibodies from camelids, or nanobodies, are a unique class of antibody
fragments with several advantageous characteristics: small monomeric size, high stability …

The TOC and TIC complexes are essential translocons that facilitate the import of the
nuclear genome-encoded preproteins across the two envelope membranes of chloroplast …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

Many proteins are transported into the endoplasmic reticulum by the universally conserved
Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and …

The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation
channel and numerous accessory factors that collectively facilitate the biogenesis of …

In eukaryotes, most secretory and membrane proteins are targeted by an N‐terminal signal
sequence to the endoplasmic reticulum, where the trimeric Sec61 complex serves as protein …

Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

SecA, an ATPase known to posttranslationally translocate secretory proteins across the
bacterial plasma membrane, also binds ribosomes, but the role of SecA's ribosome …