The multidomain protein kinases BUB1 and BUBR1 (Mad3 in yeast, worms and plants) are
central components of the mitotic checkpoint for spindle assembly (SAC). This evolutionarily …

The underlying etiologies of genetic congenital microcephaly are complex and multifactorial.
Recently, with the exponential growth in the identification and characterization of novel …

Kinetochores are the macromolecular complexes that interact with microtubules to mediate
chromosome segregation [1]. Accurate segregation requires that kinetochores make …

The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by
preventing cell division when chromosomes are not correctly attached to the spindle …

Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the
monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that …

The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle
progression until all kinetochores have attached to the mitotic spindle. In this paper, we …

The function of the essential checkpoint kinases Bub1 and BubR1 requires their recruitment
to mitotic kinetochores. Kinetochore recruitment of Bub1 and BubR1 is proposed to rely on …

The kinetochore is a supramolecular structure essential for microtubule attachment and the
mitotic checkpoint. Human blinkin/human Spc105 (hSpc105)/hKNL1 was identified originally …

Defects in centrosome, centrosomal-associated and spindle-associated proteins are the
most frequent cause of primary microcephaly (PM) and microcephalic primordial dwarfism …

During mitosis, human cells exhibit a peak of protein phosphorylation that alters the
behaviour of a significant proportion of proteins, driving a dramatic transformation in the …