Unraveling the complexities of the HDL lipidome1

A Kontush, M Lhomme, MJ Chapman - Journal of lipid research, 2013 - ASBMB
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …

LDL‐cholesterol versus HDL‐cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos

L Badimon, G Vilahur - Annals of the New York Academy of …, 2012 - Wiley Online Library
Atherosclerosis is a complex disease in which many processes contribute to lesion
development. Yet, it is well accepted that high serum levels of low‐density lipoproteins (LDL) …

Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection

K Sattler, B Levkau - Cardiovascular research, 2009 - academic.oup.com
Abstract Sphingosine-1-phosphate (S1P) has gained special attention in the high-density
lipoprotein (HDL) field because HDL is the most prominent plasma carrier of S1P and …

Sphingolipids and atherosclerosis: the dual role of ceramide and sphingosine-1-phosphate

M Piccoli, F Cirillo, A Ghiroldi, P Rota, S Coviello… - Antioxidants, 2023 - mdpi.com
Sphingolipids are bioactive molecules that play either pro-and anti-atherogenic roles in the
formation and maturation of atherosclerotic plaques. Among SLs, ceramide and sphingosine …

The changing face of HDL and the best way to measure it

SK Karathanasis, LA Freeman, SM Gordon… - Clinical …, 2017 - academic.oup.com
Abstract BACKGROUND HDL cholesterol (HDL-C) is a commonly used lipid biomarker for
assessing cardiovascular health. While a central focus has been placed on the role of HDL …

HDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applications

B Levkau - Frontiers in pharmacology, 2015 - frontiersin.org
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid contained in High-density
lipoproteins (HDL) and has drawn considerable attention in the lipoprotein field as …

Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P)

F Potì, M Simoni, JR Nofer - Cardiovascular research, 2014 - academic.oup.com
Numerous epidemiological studies documented an inverse relationship between plasma
high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease …

Adipose tissue in metabolic syndrome: onset and progression of atherosclerosis

M Luna-Luna, A Medina-Urrutia… - Archives of medical …, 2015 - Elsevier
Metabolic syndrome (MetS) should be considered a clinical entity when its different
symptoms share a common etiology: obesity/insulin resistance as a result of a multi-organ …

High‐density lipoproteins, platelets and the pathogenesis of atherosclerosis

JR Nofer, MF Brodde, BE Kehrel - Clinical and Experimental …, 2010 - Wiley Online Library
Prospective and interventional studies demonstrate an inverse relationship between plasma
high‐density lipoprotein (HDL)–cholesterol and the incidence of coronary artery disease …

HDL-cholesterol in coronary artery disease risk: function or structure?

Ó Pérez-Méndez, HG Pacheco, C Martínez-Sánchez… - Clinica Chimica …, 2014 - Elsevier
High-density lipoproteins (HDL) are inversely related with coronary artery disease (CAD)
and HDL-cholesterol is the only standardized and reproducible parameter available to …