Coumarins are a very large family of compounds containing the unique 2 H-chromen-2-one
motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at
the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

Zika virus (ZIKV) infection may be associated with severe complications in fetuses and
adults, but treatment options are limited. We performed an in silico structure-based …

Novobiocin is a member of the coumermycin family of antibiotics and is a well-established
inhibitor of DNA gyrase. Recent studies have shown that novobiocin binds to a previously …

DNA gyrase and topoisomerase IV are the bacterial type IIA topoisomerases. These are
ubiquitous nucleic acid-dependent nanomachines, essential to cell life, that solve DNA …