Valvular heart disease: shifting the focus to the myocardium

N Ajmone Marsan, V Delgado, DJ Shah… - European heart …, 2023 - academic.oup.com
Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative
valvular heart disease (VHD). However, to give an indication for valvular intervention …

Degenerative mitral regurgitation

V Delgado, N Ajmone Marsan, RO Bonow… - Nature Reviews …, 2023 - nature.com
Degenerative mitral regurgitation is a major threat to public health and affects at least 24
million people worldwide, with an estimated 0.88 million disability-adjusted life years and …

Replacement myocardial fibrosis in patients with mitral valve prolapse: relation to mitral regurgitation, ventricular remodeling, and arrhythmia

AL Constant Dit Beaufils, O Huttin, A Jobbe-Duval… - Circulation, 2021 - Am Heart Assoc
Background: Mitral valve prolapse (MVP) is a frequent disease that can be complicated by
mitral regurgitation (MR), heart failure, arterial embolism, rhythm disorders, and death. Left …

CMR in evaluating valvular heart disease: diagnosis, severity, and outcomes

SG Myerson - Cardiovascular Imaging, 2021 - jacc.org
Cardiac magnetic resonance (CMR) is a versatile imaging tool that brings much to the
assessment of valvular heart disease. Although it is best known for myocardial imaging …

[HTML][HTML] Sex differences in myocardial remodeling and extracellular volume in aortic regurgitation

M Malahfji, A Senapati, D Debs, M Saeed, B Tayal… - Scientific Reports, 2023 - nature.com
Whether sex differences exist in the cardiac remodeling related to aortic regurgitation (AR) is
unclear. Cardiac magnetic resonance (CMR) is the current non-invasive reference standard …

Extracellular volume in primary mitral regurgitation

D Kitkungvan, EY Yang, KC El Tallawi, SF Nagueh… - Cardiovascular …, 2021 - jacc.org
Objectives This study used cardiovascular magnetic resonance (CMR) to evaluate whether
elevated extracellular volume (ECV) was associated with mitral valve prolapse (MVP) or if …

[HTML][HTML] Role of cardiovascular magnetic resonance in native valvular regurgitation: a comprehensive review of protocols, grading of severity, and prediction of valve …

E Vermes, L Iacuzio, F Levy, Y Bohbot… - Frontiers in …, 2022 - frontiersin.org
Valvular regurgitation is common in developed countries with an increasing prevalence due
to the aging of the population and more accurate diagnostic imaging methods …

Reverse myocardial remodeling following valve repair in patients with chronic severe primary degenerative mitral regurgitation

B Liu, DAH Neil, M Bhabra, R Patel, TA Barker… - Cardiovascular …, 2022 - jacc.org
Objectives The aims of this study were to quantify preoperative myocardial fibrosis using late
gadolinium enhancement (LGE), extracellular volume fraction (ECV%), and indexed …

Identifying mitral valve prolapse at risk for arrhythmias and fibrosis from electrocardiograms using deep learning

GH Tison, S Abreau, J Barrios, LJ Lim, M Yang… - JACC: Advances, 2023 - jacc.org
Background Mitral valve prolapse (MVP) is a common valvulopathy, with a subset
developing sudden cardiac death or cardiac arrest. Complex ventricular ectopy (ComVE) is …

[HTML][HTML] Selection of the optimal candidate to MitraClip for secondary mitral regurgitation: beyond mitral valve morphology

T Salvatore, F Ricci, GD Dangas, BS Rana… - Frontiers in …, 2021 - frontiersin.org
Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due
to an underlying disease of the myocardium leading to disruption of the balance between …