[HTML][HTML] Nitrosative stress and its association with cardiometabolic disorders
I Pérez-Torres, L Manzano-Pech, ME Rubio-Ruíz… - Molecules, 2020 - mdpi.com
Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level
of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the …
of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the …
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease
Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …
despite extensive research, only a few drugs are available for management of the disease …
Molecularly defined circuits for cardiovascular and cardiopulmonary control
The sympathetic and parasympathetic nervous systems regulate the activities of internal
organs, but the molecular and functional diversity of their constituent neurons and circuits …
organs, but the molecular and functional diversity of their constituent neurons and circuits …
[HTML][HTML] Safety and tolerability of KarXT (xanomeline–trospium) in a phase 2, randomized, double-blind, placebo-controlled study in patients with schizophrenia
CU Correll, AS Angelov, AC Miller, PJ Weiden… - Schizophrenia, 2022 - nature.com
KarXT combines xanomeline, an M1/M4 preferring muscarinic agonist with no direct D2
receptor antagonism, with the peripherally restricted anticholinergic trospium. In …
receptor antagonism, with the peripherally restricted anticholinergic trospium. In …
Regulators of cholinergic signaling in disorders of the central nervous system
Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …
Autoimmune dysautonomia in women with silicone breast implants
Importance and objectives There is unmet medical need to understand the pathogenic
mechanism of the panoply of clinical manifestations associated with silicone breast implants …
mechanism of the panoply of clinical manifestations associated with silicone breast implants …
[HTML][HTML] A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …
Pathophysiology and pharmacology of G protein-coupled receptors in the heart
G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …
[HTML][HTML] Differential actions of muscarinic receptor subtypes in gastric, pancreatic, and colon cancer
Cancers arising from gastrointestinal epithelial cells are common, aggressive, and difficult to
treat. Progress in this area resulted from recognizing that the biological behavior of these …
treat. Progress in this area resulted from recognizing that the biological behavior of these …
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits
HTM Nguyen, ET van der Westhuizen… - British Journal of …, 2024 - Wiley Online Library
Targeting allosteric sites of M1 muscarinic acetylcholine receptors (M1 receptors) is a
promising strategy to treat neurocognitive disorders, such as Alzheimer's disease and …
promising strategy to treat neurocognitive disorders, such as Alzheimer's disease and …