TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …
fundamental role in the regulation of bone organogenesis through the activation of receptor …
Notch signaling and the skeleton
S Zanotti, E Canalis - Endocrine reviews, 2016 - academic.oup.com
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …
signaling plays an important role in skeletal development and bone remodeling. After direct …
Periodic formation of epithelial somites from human pluripotent stem cells
M Sanaki-Matsumiya, M Matsuda, N Gritti… - Nature …, 2022 - nature.com
During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …
according to the segmentation clock, becoming the foundation for the segmental pattern of …
Species-specific segmentation clock periods are due to differential biochemical reaction speeds
M Matsuda, H Hayashi, J Garcia-Ojalvo… - Science, 2020 - science.org
Although mechanisms of embryonic development are similar between mice and humans,
the time scale is generally slower in humans. To investigate these interspecies differences in …
the time scale is generally slower in humans. To investigate these interspecies differences in …
Recapitulating the human segmentation clock with pluripotent stem cells
M Matsuda, Y Yamanaka, M Uemura, M Osawa… - Nature, 2020 - nature.com
Pluripotent stem cells are increasingly used to model different aspects of embryogenesis
and organ formation. Despite recent advances in in vitro induction of major mesodermal …
and organ formation. Despite recent advances in in vitro induction of major mesodermal …
Alagille syndrome: pathogenesis, diagnosis and management
PD Turnpenny, S Ellard - European Journal of Human Genetics, 2012 - nature.com
Alagille syndrome (ALGS), also known as arteriohepatic dysplasia, is a multisystem disorder
due to defects in components of the Notch signalling pathway, most commonly due to …
due to defects in components of the Notch signalling pathway, most commonly due to …
Notch signaling in human development and disease
AL Penton, LD Leonard, NB Spinner - Seminars in cell & developmental …, 2012 - Elsevier
Mutations in Notch signaling pathway members cause developmental phenotypes that affect
the liver, skeleton, heart, eye, face, kidney, and vasculature. Notch associated disorders …
the liver, skeleton, heart, eye, face, kidney, and vasculature. Notch associated disorders …
Canonical and non-canonical Notch ligands
B D'Souza, L Meloty-Kapella, G Weinmaster - Current topics in …, 2010 - Elsevier
Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …
development and tissue homeostasis through the regulation of a variety of cell fate decisions …
The many facets of Notch ligands
B D'souza, A Miyamoto, G Weinmaster - Oncogene, 2008 - nature.com
The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …
Vertebrate segmentation: from cyclic gene networks to scoliosis
O Pourquié - Cell, 2011 - cell.com
One of the most striking features of the human vertebral column is its periodic organization
along the anterior-posterior axis. This pattern is established when segments of vertebrates …
along the anterior-posterior axis. This pattern is established when segments of vertebrates …