While glia are essential for regulating the homeostasis in the normal brain, their dysfunction
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …

Inflammation has long been associated with the pathogenesis of Parkinson's disease (PD)
but the extent to which it is a cause or consequence is sill debated. Over the past decade a …

Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …

Abstract Purpose of Review This review presents an overview of the current knowledge of
tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) molecules in inflammation …

Neuroinflammation is involved in the pathogenesis of Parkinson's disease (PD) and other
neurodegenerative disorders. We show that lack of PINK1-a mitochondrial kinase linked to …

Background PINK1 deficiency causes the autosomal recessive PARK6 variant of
Parkinson's disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the …

Parkinson's disease (PD), dementia with Lewy body (DLB), progressive supranuclear palsy
(PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) belong to a …

In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated
pyroptosis has recently garnered significant attention as a potential novel form of …

Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive
forms of Parkinson's disease. Recent work suggests that loss of mitochondrial membrane …

Phosphorylation and ubiquitination are pervasive post-translational modifications that
impact all processes inside eukaryotic cells. The role of each modification has been studied …