Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …

Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

Sex is an important determinant of brain microvessels (MVs) function and susceptibility to
cerebrovascular and neurological diseases, but underlying mechanisms are unclear. Using …

Variability in individual capacity for hepatic elimination of therapeutic drugs is well
recognized and is associated with variable expression and activity of liver enzymes and …

Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …

The blood–brain barrier (BBB) maintains brain homeostasis by controlling traffic of
molecules from the circulation into the brain. This function is predominantly dependent on …

There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …

This work was designed to clarify the absolute abundances of transporters and receptors at
different cerebral regions of the blood–brain barriers (BBB) and blood–spinal cord barrier …