Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …

Background and Purpose. Oxidative stress plays a pivotal role in early brain injury (EBI) after
subarachnoid hemorrhage (SAH). The CB1R agonist ACEA has been reported to have a …

Research on endocannabinoid signaling has greatly advanced our understanding of how
the excitability of neural circuits is controlled in health and disease. In general …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies' most often
documented side effects. Patients with CIPN experience spontaneous burning, numbness …

Dravet syndrome is a catastrophic childhood epilepsy with multiple seizure types that are
refractory to treatment. The endocannabinoid system regulates neuronal excitability so a …

Currently, there is an urgent need to better comprehend neuroplastic alterations in
cannabinoid receptors type 1 (CB1) and to understand the biological meaning of these …

Abstract Background and Purpose Activation of CB1 by exogenous agonists causes adverse
effects in vivo. Positive allosteric modulation may offer improved therapeutic potential and a …

Allosteric modulators of cannabinoid 1 receptor (CB1R) show translational promise over
orthosteric ligands due to their potential to elicit therapeutic benefit without cannabimimetic …

The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class AG protein-
coupled receptors (GPCRs) that are activated by endogenous lipids called …