Epigenetics of male infertility: the role of DNA methylation
JC Rotondo, C Lanzillotti, C Mazziotta… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …
Impact of advanced paternal age on fertility and risks of genetic disorders in offspring
A Kaltsas, E Moustakli, A Zikopoulos, I Georgiou… - Genes, 2023 - mdpi.com
The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …
owing to various variables, including a longer life expectancy, more access to contraception …
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …
the first child is conceived, either due to increased life expectancy, widespread use of …
Paternal diet programs offspring health through sperm-and seminal plasma-specific pathways in mice
AJ Watkins, I Dias, H Tsuro, D Allen… - Proceedings of the …, 2018 - National Acad Sciences
The association between poor paternal diet, perturbed embryonic development, and adult
offspring ill health represents a new focus for the Developmental Origins of Health and …
offspring ill health represents a new focus for the Developmental Origins of Health and …
Mitochondrial reactive oxygen species (ROS) production alters sperm quality
R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
The correlation between epigenetics and human reproduction represents a very interesting
field of study, mainly due to the possible transgenerational effects related to epigenetic …
field of study, mainly due to the possible transgenerational effects related to epigenetic …
Impairment of sperm DNA methylation in male infertility: a meta‐analytic study
D Santi, S De Vincentis, E Magnani, G Spaggiari - Andrology, 2017 - Wiley Online Library
Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …
The role of epigenetics in idiopathic male infertility
Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …
some specific mutations have been identified, other factors responsible for sperm defects …
Clinical genetic testing for male factor infertility: current applications and future directions
J Hotaling, DT Carrell - Andrology, 2014 - Wiley Online Library
Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could,
potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the …
potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the …
Impact of endocrine disruptors upon non-genetic inheritance
D Montjean, AS Neyroud, MG Yefimova… - International Journal of …, 2022 - mdpi.com
Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …
expression without modifying the DNA sequence. It is commonly accepted that the …