[HTML][HTML] Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
[HTML][HTML] The orexin/receptor system: molecular mechanism and therapeutic potential for neurological diseases
C Wang, Q Wang, B Ji, Y Pan, C Xu… - Frontiers in molecular …, 2018 - frontiersin.org
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …
Obesity: Current and potential pharmacotherapeutics and targets
V Narayanaswami, LP Dwoskin - Pharmacology & therapeutics, 2017 - Elsevier
Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …
[HTML][HTML] Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …
neurons that have extensive projections throughout the central nervous system and bind two …
Lateral hypothalamic orexin/hypocretin neurons: a role in reward-seeking and addiction
Orexins (synonymous with hypocretins) are recently discovered neuropeptides made
exclusively in hypothalamus. Behavioral, anatomical, and neurophysiological studies show …
exclusively in hypothalamus. Behavioral, anatomical, and neurophysiological studies show …
The dark side of food addiction
SL Parylak, GF Koob, EP Zorrilla - Physiology & behavior, 2011 - Elsevier
In drug addiction, the transition from casual drug use to dependence has been linked to a
shift away from positive reinforcement and toward negative reinforcement. That is, drugs …
shift away from positive reinforcement and toward negative reinforcement. That is, drugs …
Orexin/hypocretin role in reward: implications for opioid and other addictions
Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
Insular hypocretin transmission regulates nicotine reward
JA Hollander, Q Lu, MD Cameron… - Proceedings of the …, 2008 - National Acad Sciences
Damage to the insular cortex can profoundly disrupt tobacco addiction in human smokers,
reflected in spontaneous cessation of the tobacco habit and persistently decreased urge to …
reflected in spontaneous cessation of the tobacco habit and persistently decreased urge to …