Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive
approach for pathogen detection. The cost of high-throughput or next-generation …

Fever of Unknown Origin FUO despite a high-quality workup after a reasonable amount of
time has elapsed to rule out self-limited fevers remains a challenge. The clinician must pay …

The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …

Fever has preoccupied physicians since the earliest days of clinical medicine. It has been
the subject of scrutiny in recent decades. Historical convention has mostly determined that …

Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3° C on several
occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory …

Nuclear medicine imaging procedures play an important role in the assessment of
inflammatory diseases. With the advent of 3-dimensional anatomic imaging, there has been …

Rapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is
challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied …

Fever is not only observed in the course of a bacterial or viral infection, but can be a
symptom of, for instance, auto-immune, malignant or thromboembolic disease. Determining …

Background The differential diagnosis of Fever of Unknown Origin (FUO) is very extensive,
and includes infectious diseases (ID), neoplasms and noninfectious inflammatory diseases …

Prolonged fever of 38.3° C or higher for at least 3 weeks' duration has been termed fever of
unknown origin if unexplained after preliminary investigations. Initially codified in 1961 …