Clinical metagenomic next-generation sequencing for pathogen detection
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive
approach for pathogen detection. The cost of high-throughput or next-generation …
approach for pathogen detection. The cost of high-throughput or next-generation …
Fever of unknown origin
G Haidar, N Singh - New England Journal of Medicine, 2022 - Mass Medical Soc
Fever of Unknown Origin FUO despite a high-quality workup after a reasonable amount of
time has elapsed to rule out self-limited fevers remains a challenge. The clinician must pay …
time has elapsed to rule out self-limited fevers remains a challenge. The clinician must pay …
[HTML][HTML] Application of next generation sequencing in laboratory medicine
The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
Fever and fever of unknown origin: review, recent advances, and lingering dogma
WF Wright, PG Auwaerter - Open Forum Infectious Diseases, 2020 - academic.oup.com
Fever has preoccupied physicians since the earliest days of clinical medicine. It has been
the subject of scrutiny in recent decades. Historical convention has mostly determined that …
the subject of scrutiny in recent decades. Historical convention has mostly determined that …
[HTML][HTML] Fever of unknown origin: the value of FDG-PET/CT
IJE Kouijzer, CM Mulders-Manders… - Seminars in Nuclear …, 2018 - Elsevier
Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3° C on several
occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory …
occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory …
Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques
M Gotthardt, CP Bleeker-Rovers… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Nuclear medicine imaging procedures play an important role in the assessment of
inflammatory diseases. With the advent of 3-dimensional anatomic imaging, there has been …
inflammatory diseases. With the advent of 3-dimensional anatomic imaging, there has been …
Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department
S Riedel, JH Melendez, AT An… - American journal of …, 2011 - academic.oup.com
Rapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is
challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied …
challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied …
The diagnostic role of procalcitonin and other biomarkers in discriminating infectious from non-infectious fever
M Limper, MD De Kruif, AJ Duits, DPM Brandjes… - Journal of Infection, 2010 - Elsevier
Fever is not only observed in the course of a bacterial or viral infection, but can be a
symptom of, for instance, auto-immune, malignant or thromboembolic disease. Determining …
symptom of, for instance, auto-immune, malignant or thromboembolic disease. Determining …
Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review
Background The differential diagnosis of Fever of Unknown Origin (FUO) is very extensive,
and includes infectious diseases (ID), neoplasms and noninfectious inflammatory diseases …
and includes infectious diseases (ID), neoplasms and noninfectious inflammatory diseases …
Fever of unknown origin (FUO)–a call for new research standards and updated clinical management
WF Wright, CM Mulders-Manders, PG Auwaerter… - The American Journal of …, 2022 - Elsevier
Prolonged fever of 38.3° C or higher for at least 3 weeks' duration has been termed fever of
unknown origin if unexplained after preliminary investigations. Initially codified in 1961 …
unknown origin if unexplained after preliminary investigations. Initially codified in 1961 …