Single-particle cryo-electron tomography is an emerging technique capable of determining
the structure of proteins imaged within the native context of cells at molecular resolution …

The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1
(HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein …

Fc-mediated antibody effector functions, such as antibody-dependent cellular cytotoxicity
(ADCC), can contribute to the containment HIV-1 replication but whether such activities are …

The HIV-1 envelope is a heavily glycosylated class 1 trimeric fusion protein responsible for
viral entry into CD4+ immune cells. Developing neutralizing antibodies against the specific …

The monoclonal antibodies (MAbs) NCI05 and NCI09, isolated from a vaccinated macaque
that was protected from multiple simian immunodeficiency virus (SIV) challenges, both target …

Antibody-dependent cellular phagocytosis (ADCP) has been implicated in protection against
HIV-1. However, methods for measuring ADCP currently rely on the phagocytosis of gp120 …

Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is
associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind …

Bacteria dysbiosis has been associated with an increased risk of HIV-1 transmission and
acquisition. The prevalent idea is that bacteria dysbiosis compromises mucosal integrity and …

An alternative to lifelong antiretroviral therapy (ART) is needed to achieve durable control of
HIV-1. Here we show that adeno-associated virus (AAV)-delivery of two rhesus macaque …

As of the year 2023, there has yet to be developed an effective prophylactic vaccine against
HIV-1 infection. One likely reason for prior failures in vaccine trials is that vaccines have …