Semaphorins are a family originally identified as axonal guidance molecules. They are also
involved in tumor growth, angiogenesis, immune regulation, as well as other biological and …

The establishment of neuronal circuits requires neurons to develop and maintain
appropriate connections with cellular partners in and out the central nervous system. These …

Neurons in the central nervous system (CNS) are distinguished by the neurotransmitter
types they release, their synaptic connections, morphology, and genetic profiles. To fully …

Background: In an early stage of Alzheimer's disease (AD), before the formation of amyloid
plaques, neuronal network hyperactivity has been reported in both patients and animal …

Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on
the same dendrite, but it is unknown whether their location is random or regulated. Here, we …

Synapse formation in the mammalian brain is a complex and dynamic process requiring
coordinated function of dozens of molecular families such as cell adhesion molecules …

Although differences in DNA methylation have been associated with both syndromic and
idiopathic autism, differential methylation has not been examined previously with respect to …

Early postnatal experience shapes both inhibitory and excitatory networks in the
hippocampus. However, the underlying circuit plasticity is unclear. Using an enriched …

Maintaining an appropriate balance between excitation and inhibition is critical for neuronal
information processing. Cortical neurons can cell-autonomously adjust the inhibition they …

Previously we demonstrated that intra-hippocampal infusion of purified, Semaphorin 4D
(Sema4D) extracellular domain (ECD) into the mouse hippocampus rapidly promotes …