Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Gadsby, David C., and Angus C. Nairn. Control of CTFR Channel Gating by Phosphorylation
and Nucleotide Hydrolysis. Physiol. Rev. 79, Suppl.: S77–S107, 1999.—The cystic fibrosis …

In the mammalian heart, cardiac function is under the control of the sympathetic and
parasympathetic nervous system. All regions of the mammalian heart are innervated by …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …

The relative contributions of the rapid and slow components of the delayed rectifier
potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration …

The mechanism by which isoproterenol (ISO) prevents the prolongation of action potential
duration (APD) and refractory period (RP) by the class III antiarrhythmic agent E-4031 was …

We have developed a mathematical model of the rabbit atrial myocyte and have used it in an
examination of the ionic basis of the atrial action potential. Available biophysical data have …

It is common to experience a thumping heart during strenuous exercise or when frightened.
This increase in the force and frequency of contraction of the heart can result in an increase …