The multiple functions of RNA helicases as drivers and regulators of gene expression
CF Bourgeois, F Mortreux, D Auboeuf - Nature reviews Molecular cell …, 2016 - nature.com
RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …
mRNAs, the processing and fate of which rely on their packaging into messenger …
Therapeutics—how to treat phase separation-associated diseases
RJ Wheeler - Emerging Topics in Life Sciences, 2020 - portlandpress.com
Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …
associated proteins are able to form liquid membraneless compartments (condensates) by …
Membraneless organelles: phasing out of equilibrium
Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate
storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class …
storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class …
Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
On the origin of non-membrane-bound organelles, and their physiological function
W Stroberg, S Schnell - Journal of theoretical biology, 2017 - Elsevier
The origin of cellular compartmentalization has long been viewed as paralleling the origin of
life. Historically, membrane-bound organelles have been presented as the canonical …
life. Historically, membrane-bound organelles have been presented as the canonical …
Dead or alive: DEAD-box ATPases as regulators of ribonucleoprotein complex condensation
K Weis - Biological Chemistry, 2021 - degruyter.com
DEAD-box ATPase proteins are found in all clades of life and have been associated with a
diverse array of RNA-processing reactions in eukaryotes, bacteria and archaea. Their highly …
diverse array of RNA-processing reactions in eukaryotes, bacteria and archaea. Their highly …
RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa
S Kramer - Wiley Interdisciplinary Reviews: RNA, 2014 - Wiley Online Library
Ribonucleoprotein (RNP) granules are important posttranscriptional regulators of
messenger RNA (mRNA) fate. Several types of RNP granules specifically regulate gene …
messenger RNA (mRNA) fate. Several types of RNP granules specifically regulate gene …
A subset of patients with acute myeloid leukemia has leukemia cells characterized by chemokine responsiveness and altered expression of transcriptional as well as …
AK Brenner, H Reikvam, Ø Bruserud - Frontiers in immunology, 2016 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive and heterogeneous bone marrow
malignancy, the only curative treatment being intensive chemotherapy eventually in …
malignancy, the only curative treatment being intensive chemotherapy eventually in …
Characterization of a homolog of DEAD-box RNA helicases in Toxoplasma gondii as a marker of cytoplasmic mRNP stress granules
AA Cherry, S Ananvoranich - Gene, 2014 - Elsevier
Toxoplasma gondii is an obligate intracellular protozoan which infects one-third of the
human population. Due to its high infection prevalence, Toxoplasma offers an ideal system …
human population. Due to its high infection prevalence, Toxoplasma offers an ideal system …
Co-Expression networks identify DHX15 RNA helicase as a B cell regulatory factor
T Detanico, R Virgen-Slane, S Steen-Fuentes… - Frontiers in …, 2019 - frontiersin.org
Genome-wide co-expression analysis is often used for annotating novel gene functions from
high-dimensional data. Here, we developed an R package with a Shiny visualization app …
high-dimensional data. Here, we developed an R package with a Shiny visualization app …