Can we safely target the WNT pathway?
M Kahn - Nature reviews Drug discovery, 2014 - nature.com
WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …
WNT/F rizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3
JP Dijksterhuis, J Petersen… - British journal of …, 2014 - Wiley Online Library
The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …
[HTML][HTML] WNT-5A: signaling and functions in health and disease
K Kumawat, R Gosens - Cellular and Molecular Life Sciences, 2016 - Springer
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …
Aβ1–42 oligomer‐induced leakage in an in vitro blood–brain barrier model is associated with up‐regulation of RAGE and metalloproteinases, and down‐regulation …
W Wan, L Cao, L Liu, C Zhang, B Kalionis… - Journal of …, 2015 - Wiley Online Library
Accumulating evidence indicates that abnormal deposition of amyloid‐β (Aβ) peptide in the
brain is responsible for endothelial cell damage and consequently leads to blood–brain …
brain is responsible for endothelial cell damage and consequently leads to blood–brain …
WNT secretion and signalling in human disease
P Herr, G Hausmann, K Basler - Trends in molecular medicine, 2012 - cell.com
Wnt signalling, a key pathway involved in various aspects of embryonic development, also
underlies many human diseases, in particular, cancer. Research focused on signal …
underlies many human diseases, in particular, cancer. Research focused on signal …
Neuroprotective effects of resveratrol against Aβ administration in rats are improved by lipid-core nanocapsules
RL Frozza, A Bernardi, JB Hoppe, AB Meneghetti… - Molecular …, 2013 - Springer
Abstract Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual
decline in cognitive function, is characterized by the presence of neuritic plaques composed …
decline in cognitive function, is characterized by the presence of neuritic plaques composed …
The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
P Lopez-Bergami, G Barbero - Cancer and Metastasis Reviews, 2020 - Springer
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its
overexpression has been implicated in the progression of several tumor types by promoting …
overexpression has been implicated in the progression of several tumor types by promoting …
Wnt/β-catenin signaling in Alzheimer's disease
Alzheimer's disease is a neurodegenerative disorder that causes a progressive decline of
mental and cognitive processes such as memory, judgment and reasoning. We proposed …
mental and cognitive processes such as memory, judgment and reasoning. We proposed …
Rho Kinase Inhibitor Fasudil Protects against β‐Amyloid‐Induced Hippocampal Neurodegeneration in Rats
Y Song, X Chen, LY Wang, W Gao… - CNS neuroscience & …, 2013 - Wiley Online Library
Background and purpose Alzheimer's disease (AD) is a progressive neurodegenerative
disorder, and Aβ‐induced neuronal damage is the major pathology of AD. There is …
disorder, and Aβ‐induced neuronal damage is the major pathology of AD. There is …
Vertebrate Wnt5a–At the crossroads of cellular signalling
Wnt signalling is an essential pathway in embryogenesis, differentiation, cell motility,
development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can …
development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can …