Trypanosoma cruzi acute infections often go unperceived, but one third of chronically
infected individuals die of Chagas disease, showing diverse manifestations affecting the …

Protein kinases represent promising drug targets for a number of human and animal
diseases. The recent completion of the sequenced genomes of three human-infective …

The protozoan parasite Trypanosoma brucei is the causative agent of human African
sleeping sickness and related animal diseases, and it has over 170 predicted protein …

Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment
of the transcriptional regulators and the transcription machinery to promoter chromatin is …

The replication and segregation of organelles producing two identical daughter cells must
be precisely controlled during the cell cycle progression of eukaryotes. In kinetoplastid …

Protein phosphorylation is a reversible post-translational modification essential for the
regulation of several signal transduction pathways and biological processes in the living …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

The African sleeping sickness parasite Trypanosoma brucei evades the host immune
system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …