The brain is hyperexcitable in migraine

SK Aurora, F Wilkinson - Cephalalgia, 2007 - journals.sagepub.com
Migraine is a very common disorder occurring in 20% of women and 6% of men. Central
neuronal hyperexcitability is proposed to be the putative basis for the physiological …

Migraine understood as a sensory threshold disease

KP Peng, A May - Pain, 2019 - journals.lww.com
Migraine encompasses a broader spectrum of sensory symptoms than just headache. These
“other” symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many …

Anatomical alterations of the visual motion processing network in migraine with and without aura

C Granziera, AFM DaSilva, J Snyder, DS Tuch… - PLoS …, 2006 - journals.plos.org
Background Patients suffering from migraine with aura (MWA) and migraine without aura
(MWoA) show abnormalities in visual motion perception during and between attacks …

Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain

N Boulloche, M Denuelle, P Payoux, N Fabre… - Journal of Neurology …, 2010 - jnnp.bmj.com
Objective Photophobia is an abnormal sensitivity to light experienced by migraineurs and is
perhaps caused by cortical hyperexcitability. In clinical studies, an inter-relation between …

Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura

R Datta, GK Aguirre, S Hu, JA Detre… - …, 2013 - journals.sagepub.com
Objective The objective of this study was to compare the interictal cortical response to a
visual stimulus between migraine with aura (MWA), migraine without aura (MwoA), and …

Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: a narrative review

A Klein, CJ Schankin - Headache: The Journal of Head and …, 2021 - Wiley Online Library
Objective The aim of this narrative review is to explore the relationship between visual snow
syndrome (VSS), migraine, and a group of other perceptual disorders. Background VSS is …

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine

CN Sang, NM Ramadan, RG Wallihan… - …, 2004 - journals.sagepub.com
Glutamatergic hyperactivity is implicated migraine pathogenesis. Also, LY293558, an α-
amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate (KA) receptor …

Brain hyperexcitability: the basis for antiepileptic drugs in migraine prevention

KM Welch - Headache: The Journal of Head and Face Pain, 2005 - Wiley Online Library
Abnormal brain excitability may provide the susceptibility for triggering migraine attacks.
Antiepileptic drugs may diminish neuronal excitability and consequently reduce the …

Visual stimuli are common triggers of migraine and are associated with pattern glare

DE Harle, AJ Shepherd… - Headache: The Journal of …, 2006 - Wiley Online Library
Objective.—To investigate the associations between interictal pattern glare, visual stress,
and visual triggers of migraine. Background.—There has been relatively little research on …

Altered motion perception in migraineurs: evidence for interictal cortical hyperexcitability

A Antal, J Temme, MA Nitsche, ET Varga… - …, 2005 - journals.sagepub.com
Much research on visual functions in migraine has pinpointed the existence of abnormal
visual processing between attacks. However, it is not clear if this is due to cortical hyper-or …