Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …
Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy
L Zhang, J Li, L Ouyang, B Liu, Y Cheng - Cancer letters, 2016 - Elsevier
Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the
lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 …
lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 …
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo
Y Fu, L Hong, J Xu, G Zhong, Q Gu, Q Gu, Y Guan… - Autophagy, 2019 - Taylor & Francis
Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/
autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for …
autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for …
On ATG4B as drug target for treatment of solid tumours—the knowns and the unknowns
A Agrotis, R Ketteler - Cells, 2019 - mdpi.com
Autophagy is an evolutionary conserved stress survival pathway that has been shown to
play an important role in the initiation, progression, and metastasis of multiple cancers; …
play an important role in the initiation, progression, and metastasis of multiple cancers; …
A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells
PXE Mouratidis, I Rivens, G Ter Haar - International Journal of …, 2015 - Taylor & Francis
Purpose: The pleiotropic effects of heat on cancer cells have been well documented. The
biological effects seen depend on the temperature applied, and the heating duration. In this …
biological effects seen depend on the temperature applied, and the heating duration. In this …
Targeting Atg4B for cancer therapy: Chemical mediators
G Yang, Y Li, Y Zhao, L Ouyang, Y Chen, B Liu… - European Journal of …, 2021 - Elsevier
Atg4, a pivotal macroautophagy/autophagy-related cysteine protein family, which regulate
autophagy through either cleaving Atg8 homologs for its further lipidation or delipidating …
autophagy through either cleaving Atg8 homologs for its further lipidation or delipidating …
[HTML][HTML] Identification of kinases and phosphatases that regulate ATG4B activity by siRNA and small molecule screening in cells
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system
required for autophagosome formation, maturation and closure. Members of the ATG4 and …
required for autophagosome formation, maturation and closure. Members of the ATG4 and …
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. “Cascade”)
Humulus lupulus (hop plant) has long been used in traditional medicine as a sedative and
antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic …
antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic …
Cytotoxic, Antibacterial, and Antioxidant Activities of the Leaf Extract of Sinningia bullata
PJ Chen, ES Lin, HH Su, CY Huang - Plants, 2023 - mdpi.com
Sinningia bullata is a tuberous member of the flowering plant family Gesneriaceae. Prior to
this work, the antibacterial, antioxidant, and cytotoxic properties of S. bullata were …
this work, the antibacterial, antioxidant, and cytotoxic properties of S. bullata were …
The regulatory factors and pathological roles of autophagy‐related protein 4 in diverse diseases: Recent research advances
Macroautophagy (autophagy) is an evolutionarily conserved and dynamic
degradation/recycling pathway in which portions of the cytoplasm, such as dysfunctional …
degradation/recycling pathway in which portions of the cytoplasm, such as dysfunctional …