Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy

L Zhang, J Li, L Ouyang, B Liu, Y Cheng - Cancer letters, 2016 - Elsevier
Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the
lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 …

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

Y Fu, L Hong, J Xu, G Zhong, Q Gu, Q Gu, Y Guan… - Autophagy, 2019 - Taylor & Francis
Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/
autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for …

On ATG4B as drug target for treatment of solid tumours—the knowns and the unknowns

A Agrotis, R Ketteler - Cells, 2019 - mdpi.com
Autophagy is an evolutionary conserved stress survival pathway that has been shown to
play an important role in the initiation, progression, and metastasis of multiple cancers; …

A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells

PXE Mouratidis, I Rivens, G Ter Haar - International Journal of …, 2015 - Taylor & Francis
Purpose: The pleiotropic effects of heat on cancer cells have been well documented. The
biological effects seen depend on the temperature applied, and the heating duration. In this …

Targeting Atg4B for cancer therapy: Chemical mediators

G Yang, Y Li, Y Zhao, L Ouyang, Y Chen, B Liu… - European Journal of …, 2021 - Elsevier
Atg4, a pivotal macroautophagy/autophagy-related cysteine protein family, which regulate
autophagy through either cleaving Atg8 homologs for its further lipidation or delipidating …

[HTML][HTML] Identification of kinases and phosphatases that regulate ATG4B activity by siRNA and small molecule screening in cells

N Pengo, K Prak, JR Costa, C Luft, A Agrotis… - Frontiers in Cell and …, 2018 - frontiersin.org
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system
required for autophagosome formation, maturation and closure. Members of the ATG4 and …

Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. “Cascade”)

M Forino, S Pace, G Chianese… - Journal of Natural …, 2016 - ACS Publications
Humulus lupulus (hop plant) has long been used in traditional medicine as a sedative and
antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic …

Cytotoxic, Antibacterial, and Antioxidant Activities of the Leaf Extract of Sinningia bullata

PJ Chen, ES Lin, HH Su, CY Huang - Plants, 2023 - mdpi.com
Sinningia bullata is a tuberous member of the flowering plant family Gesneriaceae. Prior to
this work, the antibacterial, antioxidant, and cytotoxic properties of S. bullata were …

The regulatory factors and pathological roles of autophagy‐related protein 4 in diverse diseases: Recent research advances

F Xia, P Liu, M Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Macroautophagy (autophagy) is an evolutionarily conserved and dynamic
degradation/recycling pathway in which portions of the cytoplasm, such as dysfunctional …