Carbapenem-resistant gram-negative bacterial infections in children

D Aguilera-Alonso, L Escosa-García… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Carbapenem-resistant organisms (CRO) are a major global public health threat.
Enterobacterales hydrolyze almost all β-lactams through carbapenemase production …

Ceftolozane/tazobactam for difficult-to-treat Pseudomonas aeruginosa infections: a systematic review of its efficacy and safety for off-label indications

AE Maraolo, M Mazzitelli, EM Trecarichi… - International journal of …, 2020 - Elsevier
ABSTRACT Ceftolozane/tazobactam (C/T) is a novel β-lactam/β-lactamase inhibitor
combination targeting Enterobacteriaceae and Pseudomonas aeruginosa (PA). It is …

Ceftolozane-tazobactam against Pseudomonas aeruginosa cystic fibrosis clinical isolates in the hollow-fiber infection model: challenges imposed by hypermutability …

JR Tait, M Harper, S Cortés-Lara… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …

A novel membrane-disruptive antimicrobial peptide from frog skin secretion against cystic fibrosis isolates and evaluation of anti-MRSA effect using Galleria mellonella …

Y Yuan, Y Zai, X Xi, C Ma, L Wang, M Zhou… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Antimicrobial peptides from amphibian skin secretion are a promising source for the
development of alternative antibiotics against the urgent antibiotic resistance. Methicillin …

[HTML][HTML] A Rapid and Sensitive Detection Method for Pseudomonas aeruginosa Using Visualized Recombinase Polymerase Amplification and Lateral Flow Strip …

H Yang, Y Wang, Q Yang, H Fan, L Wang… - Frontiers in cellular …, 2021 - frontiersin.org
Pseudomonas aeruginosa is a common opportunistic pathogen that causes acute
nosocomial necrotizing pneumonia and is the predominant source of chronic lung infections …

Mechanisms of high-level ceftolozane/tazobactam resistance in Pseudomonas aeruginosa from a severely neutropenic patient and treatment success from synergy …

W So, J Shurko, R Galega, R Quilitz… - Journal of …, 2019 - academic.oup.com
AMK, amikacin; ATM, aztreonam; CAZ, ceftazidime; CAZ/AVI, ceftazidime/avibactam; CIP,
ciprofloxacin; CST, colistin; C/T, ceftolozane/tazobactam; DOR, doripenem; FEP, cefepime; …

[HTML][HTML] Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic …

N Molchanova, H Wang, PR Hansen, N Høiby… - Frontiers in …, 2019 - frontiersin.org
Pseudomonas aeruginosa infection is a predominant cause of morbidity and mortality in
patients with cystic fibrosis infection and with a compromised immune system. Emergence of …

[HTML][HTML] Ceftolozane/Tazobactam for Resistant Drugs Pseudomonas aeruginosa Respiratory Infections: A Systematic Literature Review of the Real-World Evidence

LG Giaccari, MC Pace, MB Passavanti, F Gargano… - Life, 2021 - mdpi.com
Background: Ceftolozane/tazobactam (C/T) is a β-lactam/β-lactamase inhibitor combination
that mainly targets Gram-negative bacteria. The current international guidelines recommend …

[HTML][HTML] Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data

S Garazzino, E Altieri, E Silvestro, G Pruccoli… - Frontiers in …, 2020 - frontiersin.org
Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor
combination recently approved for treatment of both complicated intra-abdominal and …

Ceftazidime/avibactam and ceftolozane/tazobactam: novel therapy for multidrug resistant gram negative infections in children

BA Rodriguez, JE Girotto… - Current Pediatric …, 2018 - ingentaconnect.com
The rise in Multidrug-resistant (MDR) infections has become a significant problem in both
the developing countries and in the United States (US). Specifically, MDR gram-negative …