In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …

Drug addiction and obesity appear to share several properties. Both can be defined as
disorders in which the saliency of a specific type of reward (food or drug) becomes …

High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …

Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

Drug use and relapse involve learned associations between drug-associated environmental
cues and drug effects. Extinction procedures in the clinic can suppress conditioned …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

Extinction is a form of inhibitory learning that suppresses a previously conditioned response.
Both fear and drug seeking are conditioned responses that can lead to maladaptive …

The nature of addiction is often debated along moral versus biological lines. However,
recent advances in neuroscience offer insights that might help bridge the gap between these …

Cues associated with rewards, such as food or drugs of abuse, can themselves acquire
motivational properties. Acting as incentive stimuli, such cues can exert powerful control …