Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
DNA methylation and its basic function
LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
Abstract Motivation: The Illumina Infinium 450 k DNA Methylation Beadchip is a prime
candidate technology for Epigenome-Wide Association Studies (EWAS). However, a …
candidate technology for Epigenome-Wide Association Studies (EWAS). However, a …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
DNA methylation methods: Global DNA methylation and methylomic analyses
S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …
significant involvement for numerous biological processes in health and disease. The …
Statistical and integrative system-level analysis of DNA methylation data
AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Tobacco smoking leads to extensive genome-wide changes in DNA methylation
S Zeilinger, B Kühnel, N Klopp, H Baurecht… - PloS one, 2013 - journals.plos.org
Environmental factors such as tobacco smoking may have long-lasting effects on DNA
methylation patterns, which might lead to changes in gene expression and in a broader …
methylation patterns, which might lead to changes in gene expression and in a broader …
[HTML][HTML] High density DNA methylation array with single CpG site resolution
M Bibikova, B Barnes, C Tsan, V Ho, B Klotzle, JM Le… - Genomics, 2011 - Elsevier
We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …
allows high-throughput methylation profiling of the human genome. The new high density …
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …