The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

Heat shock proteins 70 (HSP70s) are steadily gaining more attention in the field of plant
biotic interactions. Though their regulation and activity in plants are much less well …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Some of the most challenging stress conditions that organisms encounter during their
lifetime involve the transient accumulation of reactive oxygen and chlorine species …

Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

Redox networks in the cell integrate signaling pathways that control metabolism, energetics,
cell survival, and death. The physiological second messengers that modulate these …

Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor
that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by …

Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …