The maturation of ovarian follicles involves several sequential stages: initiation, growth,
selection, ovulation, and luteinization (Fig. 1). Although the factor (s) that initiates the growth …

The molecular basis of many forms of male infertility is poorly defined. One area of research
that has been studied intensely is the integrity of the DNA in the nucleus of mature …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

▪ Abstract The majority of ovarian follicles undergo atresia, a hormonally controlled apoptotic
process. Monitoring apoptotic DNA fragmentation provides a quantitative and sensitive …

ABSTRACT A detailed understanding of the hormonal regulation of spermatogenesis is
required for the informed assessment and management of male fertility and, conversely, for …

Programmed cell death is an evolutionarily conserved cell death process that plays a major
role during normal development and homeostasis. In many cases, the ordered execution of …

The present study was conducted to detect sperm apoptosis in fresh and frozen semen and
to determine its relationship with bull fertility. Three ejaculates were collected from five …

This article reviews results on diVerentiation, structure, and regulation of Leydig cells in the
testes of rodents and men. Two different populations—fetal and adult Leydig cells—can be …

Short term exposure of the testis to heat causes degeneration of germ cells. However, the
mechanisms underlying this process are poorly understood. The major objectives of this …

Identification of novel neurohormones that regulate the reproductive axis is essential for the
progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) …